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Updated: Jun 14, 2025

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镜像随机非标准集成发现 (MI-RaPID) 技术为矩阵金属酶7产生高度稳定和选择性的宏环抑制剂

Hiba Ghareeb1, Choi Yi Li2, Anjana Shenoy3

  • 1Institute of Chemistry, The Center for Nanoscience and Nanotechnology, Casali Center of Applied Chemistry, The Hebrew University of Jerusalem, Jerusalem, 9190401, Israel.

Angewandte Chemie (International ed. in English)
|August 31, 2024
PubMed
概括

研究人员开发了一种新技术,可以制造抗蛋白酶的宏循环,这些可以特别抑制矩阵金属酶7 (MMP7). 这种,D'20,有效地向MMP7,显示了癌症治疗发展的潜力.

关键词:
化学蛋白质合成 化学蛋白质合成镜像蛋白质是一种镜像蛋白质.原生化学结合原生化学结合.随机非标准集成发现 (RaPID)矩阵金属蛋白质酶是一种金属蛋白质.

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Role of Matrix Metalloproteases in Degradation of ECM01:23

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
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