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Updated: Jun 14, 2025

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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[法苏迪尔通过促进线粒和抑制NLRP3炎症酶激活来改善APP/PS1转基因小鼠的认知功能]

Huaijuan Liu1, Peijun Zhang1, Jingwen Yu1

  • 1The Key Laboratory of Molecular Cellular Immunology in Datong, Institute of Brain Science, Shanxi Datong University, Datong 037009, China.

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
|August 31, 2024
PubMed
概括

法苏迪尔治疗改善了小鼠的认知功能,并减少了粉样蛋白前体蛋白/前列林-1 (APP/PS1) 的神经元损伤. 这种效应与增强的线粒细胞衰变和抑制的核酸结合性寡聚化域类受体家族含林域3 (NLRP3) 炎症酶激活有关.

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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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