氨基西林与安慰剂用于降低A组 estreptococcal 喉炎儿童的症状:一个随机的,多中心的,双盲的,非劣等性试验
Renato Gualtieri1, Charlotte Verolet1, Chiara Mardegan1
1Division of General Pediatrics, Department of Pediatrics, Gynaecology and Obstetrics, Geneva University Children's Hospital and University of Geneva, Geneva, Switzerland.
European journal of pediatrics
|August 31, 2024
概括
对于患有链球菌喉的儿童,安慰剂在减少发烧持续时间方面与阿莫西西林同样有效. 抗生素对缓解症状和并发症的益处有限,支持更谨慎的处方方法.
科学领域:
- 儿童传染病 儿童传染病
- 药理学和治疗学 药理学和治疗学
背景情况:
- 甲型链球菌 (GAS) 喉炎是儿科初级保健中常见的诊断.
- 对GAS喉炎的抗生素治疗主要用于缩短症状持续时间,因为其在预防非补充性并发症方面的有效性有限.
- 目前的研究调查了阿莫西西林与安慰剂在儿科GAS喉炎的症状管理方面的比较有效性.
研究的目的:
- 确定安慰剂是否与阿莫西西林相比在减少患有GAS喉炎的儿童发烧持续时间方面不劣.
- 为了比较阿莫西西林和安慰剂对疼痛强度和并发症发生率的影响.
主要方法:
- 这是一项随机对照试验,涉及88名年龄在3至15岁的儿童,他们确诊患有GAS喉炎.
- 参与者接受了6天的阿莫西西林疗程或安慰剂.
- 主要结局是发烧持续时间;次要结局包括疼痛强度和并发症率.
主要成果:
- 阿莫西西林和安慰剂组之间发烧持续时间的平均差异很小 (2.0-2.8小时),达到非劣势值.
- 在7天内,两组之间没有观察到疼痛强度的显著差异.
- 治疗失败和并发症的发生率在阿莫西西林和安慰剂组中都很低,而且相似.
结论:
- 避孕药在减少儿科链球菌喉炎发烧持续时间方面与阿莫西西林无差.
- 与安慰剂相比,抗生素治疗在症状持续时间和疼痛缓解方面提供了有限的额外益处.
- 研究结果支持在儿童中治疗链球菌喉炎时使用更明智的抗生素处方策略.
相关概念视频
01:30Acute Pharyngitis
498
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
498
01:26Tonsillitis II: Management
105
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
105
01:23Chronic Pharyngitis
1.4K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
1.4K
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
335
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
335
01:30Tonsillitis I: Introduction
216
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
216
01:26Peptic Ulcer Disease IV: Management
78
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
78