关于宫癌的临床指南 (2023)
Luis Manso1, Avinash Ramchandani-Vaswani2, Ignacio Romero3
1Medical Oncology Department, Hospital Univ. 12 de Octubre, Madrid, Spain. lmanso@salud.madrid.org.
概括
子宫癌 (CC) 影响全球女性,与人类乳头瘤病毒 (HPV) 有关. 在HPV疫苗接种,查和免疫治疗方面的进展正在改善全球CC患者的生存率.
科学领域:
- 在瘤学瘤学.
- 妇科瘤学 妇科瘤学
- 公共卫生 公共卫生
背景情况:
- 宫癌 (CC) 是一个重要的全球健康问题,排名为第四最常见的癌症和女性死亡原因.
- 高风险的人类乳头瘤病毒 (HPV) 感染是CC的主要原因.
- 在拥有HPV疫苗接种/查计划的高收入国家和缺乏这些计划的发展中国家之间存在CC发病率和死亡率的差异.
研究的目的:
- 提供关于宫癌诊断,治疗和随访的当前证据的全面概述.
- 为管理宫癌的临床实践制定基于证据的建议.
- 解决CC治疗的不断变化的局面,包括免疫治疗的作用.
主要方法:
- 对有关宫癌诊断和管理的相关文献进行系统审查.
- 对手术,放射治疗,化疗和免疫治疗干预的临床试验数据的分析.
- 综合证据,制定临床建议.
主要成果:
- 早期的CC治疗包括手术或放射治疗.
- 同时化学放射疗法 (CRT) 是局部晚期的标准,免疫疗法正在出现.
- 免疫疗法改善了复发性或转移性CC的整体存活率 (OS),当与化疗 (含或不含贝瓦西祖马布) 或单独治疗结合时.
结论:
- 有效的CC管理需要采用多模式方法,整合疫苗接种,查和先进疗法.
- 免疫疗法代表了显著的进步,特别是对于晚期和转移性宫癌.
- 标准化,基于证据的指导方针对于优化全球CC患者的治疗结果至关重要.
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