对用于人类衰老和死亡量化的表型和表观遗传钟进行系统审查
Brandon Warner1, Edward Ratner1, Anirban Datta1
1Verseon International Corp., Fremont, CA 94538, USA.
Aging
|August 31, 2024
概括
生物钟,包括表观遗传和表型类型,测量衰老. 本综述系统地调查了33个基于人类的时钟,详细介绍了它们的性能和未来衰老干预研究的方法.
科学领域:
- 生物遗传学 生物遗传学
- 生物标志物 生物标志物
- 计算生物学 计算生物学
背景情况:
- 衰老是人类疾病和死亡的主要原因.
- 生物钟对于测量衰老和确定干预措施至关重要.
- 表型和表观遗传时钟为评估衰老提供了不同的方法.
研究的目的:
- 系统地审查基于人类的表观遗传和表型时钟.
- 分析这些老化的时钟的预测性能和方法.
- 确定用于表型时钟的关键临床生物标志物.
主要方法:
- 对表观遗传和表型时钟的系统文献综述.
- 排除了线粒体 (癌症风险) 和非人类的时钟.
- 预测性能的分析,统计/机器学习技术和有影响力的生物标志物.
主要成果:
- 审查了33个不同的生物钟 (表观遗传和表型).
- 详细说明了每个时钟对时间表年龄和死亡率的预测准确性.
- 确定了驱动表型时钟精度的关键临床测量.
结论:
- 表观遗传钟在预测时间年龄方面表现出很高的准确性.
- 现型时钟显示出比时间年龄更优越的死亡率预测.
- 本综述提供了关于生物钟研究和未来方向的全面概述.
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