碳点介导自然产品抗菌活性的改善
Babar Khan1, Jie Zhang1, Samran Durrani1
1State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, P. R. China.
ACS applied materials & interfaces
|August 31, 2024
概括
来自真菌内细胞的新型碳点 (CD) 显示出对抗药物耐药微生物的强有力的抗菌活性. 这些Du-CD还可以增强良好的生物相容性和良好的伤口愈合,提供了一个有前途的新疗法.
科学领域:
- 微生物学 微生物学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 耐药微生物的增加需要开发新型抗菌剂.
- 自然产品为发现新的治疗化合物提供了丰富的来源.
- 碳点 (CD) 正在成为具有潜在生物医学应用的多功能纳米材料.
研究的目的:
- 为了合成和表征蓝色发射,从内生植物 *Diaporthe unshiuensis* YSP3.3.中带有正电荷的碳点 (Du-CDs).
- 评估Du-CDs对细菌和真菌的抗菌疗效,包括它们对生物膜形成的影响.
- 在小鼠模型中评估Du-CDs的伤口愈合潜力和生物相容性.
主要方法:
- 使用真菌提取物的一步溶热合成Du-CDs.
- 抗微生物活性测定 (最小抑制度).
- 生物膜抑制测定.生物膜抑制测定.
- 在小鼠的体内伤口愈合研究.
主要成果:
- 与原始提取物相比,du-CDs显示了对细菌和真菌的增强抗菌活性.
- 观察到低的最小抑制度和显著的生物膜形成抑制.
- 在小鼠模型中,du-CDs促进了加速的伤口愈合,具有良好的生物相容性.
- 作用机制包括细胞膜损伤和细胞分裂周期中断.
结论:
- 的天然产品可以有效地转化为具有强大的抗微生物特性的光碳点.
- 双CDs代表了一种有前途的新型抗微生物药物类别,具有用于感染治疗和伤口愈合的双重功能.
- 这种方法提供了一种可持续和创新的策略,用于打击微生物感染和解决抗菌素耐药性问题.
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