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Updated: Jun 14, 2025

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
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In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

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在唐氏综合征回归障碍中的JAK抑制

Angela L Rachubinski1, Lina R Patel2, Elise M Sannar3

  • 1Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, 12700 East 19(th) Avenue, Aurora, CO 80045, United States; Department of Pediatrics, Section of Developmental Pediatrics, University of Colorado Anschutz Medical Campus, 13123 E. 16(th) Ave. B065 Aurora, CO 80045, United States.

Journal of neuroimmunology
|August 31, 2024
PubMed
概括

唐氏综合征回归障碍 (DRSD) 可能会通过像托法西替尼这样的JAK抑制剂得到改善. 这项研究观察到,患有唐氏综合征 (DS) 的青少年和年轻成年人经历神经衰退的症状有所改善.

关键词:
卡塔托尼亚 (Catatonia) 是一个地区.唐氏综合征回归障碍 (DSRD)干扰素 干扰素 干扰素抑制了JAK的发生.托法西提尼布 (tofacitinib) 是一种可靠的药物.

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