长期有效性,安全性和耐受性,包括行为和执行功能,在儿科患者的辅助lacosamide治疗期间,患有不受控制的
Mark Kristof Farkas1, Iryna Makedonska2, Cynthia Beller3
1Pediatric Center, Semmelweis University, Bókay János u. 53-54, Budapest 1083, Hungary.
Epilepsy & behavior : E&B
|August 31, 2024
概括
长期的辅助拉科萨米德 (LCM) 对于儿科是有效的,耐受性很好,显示持续的控制和稳定的行为. 这种治疗没有证明儿童的执行功能恶化.
科学领域:
- 儿科神经学 儿科神经学
- 的治疗方法 治疗
- 药理学 药理学是指药理学的学科.
背景情况:
- 症影响着全球相当数量的儿童.
- 儿童的长期治疗选择对于治疗慢性疾病至关重要.
- 对儿科患者来说,评估抗药对行为和认知的影响至关重要.
研究的目的:
- 评估辅助拉科萨米德 (LCM) 的长期疗效,安全性和耐受性,在患有焦点发作或泛发作的儿科患者中.
- 评估LCM对儿童长期治疗期间行为和执行功能的影响.
主要方法:
- 两项开放扩展试验 (NCT00938912,NCT01964560) 涉及905名患有的儿科患者.
- 结果包括治疗的延续,发作频率的减少和不良事件的评估.
- 行为和执行功能使用阿肯巴赫儿童行为检查清单 (CBCL) 和执行功能的行为评级清单 (BRIEF) 进行了评估.
主要成果:
- 在焦点发作的发作中,高1年保留率 (80%) 和显著的发作频率减少 (中位数为60.4%).
- 超过75%的患者表现出改善,根据医生和护理人员的全球印象尺度.
- 治疗引起的不良事件很常见 (82.8%),最常见的是炎症和上呼吸道感染;行为和执行功能保持稳定或改善.
结论:
- 长期的辅助拉科萨米德 (LCM) 是有效的,并且在患有焦点发作或泛发作的儿童中通常耐受良好.
- 辅助LCM治疗没有导致儿科患者的行为或执行功能明显恶化.
- 这项研究支持使用LCM作为儿科的长期治疗选择.
更多相关视频
09:57Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
2.6K
06:04Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
Published on: August 16, 2024
780
相关概念视频
01:20Antiepileptic Drugs: Potassium Channel Activators
150
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
150
01:14Antiepileptic Drugs: Glutamate Antagonists
300
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
300
01:20Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
273
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
273
01:08Antiepileptic Drugs: Sodium Channel Blockers
459
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
459
01:17Antiepileptic Drugs: Calcium Channel Blockers
347
Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
347
01:24Arteries of the Lower Limbs
181
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
181