室外温度和雷诺现象在患有全身性硬化症的人群中自我报告的严重程度的关联:一个以硬化皮肤病患者为中心的干预网络队列研究
Gabrielle Virgili-Gervais1, Bianca Matthews1, Elsa-Lynn Nassar2
1Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
The Lancet. Rheumatology
|August 31, 2024
概括
雷诺现象的严重程度在极端寒冷和高温下加重,在25°C以上观察到显著增加,可能是由于空调. 温度模式应为系统性硬化症患者的临床管理和试验设计提供信息.
科学领域:
- 类风湿病学 类风湿病学
- 环境健康 环境健康
- 临床流行病学 临床流行病学
背景情况:
- 雷诺现象是系统性硬化症的主要表现.
- 发作通常是由冷暴露和温度波动引发的.
- 以前的研究表明,季节性影响雷诺现象的结果.
研究的目的:
- 调查环境温度与雷诺现象严重程度之间的关联.
- 为了绘制整个温度谱的关系.
- 为临床实践和研究设计提供信息.
主要方法:
- 利用了来自于硬质皮肤病患者中心干预网络队列的数据.
- 收集了纵向雷诺现象严重程度评估 (0-10 NRS).
- 使用爱荷华州环境介质网提取了每日温度和"感觉"温度数据,并使用带有基线的线性混合模型进行分析.
主要成果:
- 分析了2,243名参与者的20233项评估 (88%为女性,82%为白人,平均年龄为54.8岁).
- 严重程度在-25°C (6.8分) 达到峰值,在25°C (2.6分) 最低.
- 严重程度在25°C以上显著增加,在40°C时达到5.6点,并且在极寒中也增加.
结论:
- 雷诺病现象的严重程度由极度寒冷和高温加剧,后者可能与空调使用有关.
- 温度变化显著影响疾病的严重程度.
- 对雷诺现象的临床管理策略和干预试验设计应纳入温度考虑.
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