通过使用斑点跟踪回声心脏成像 (speckle tracking echocardiography) 调查内贝瓦西祖马布治疗对左心功能的影响
Mehmet Şahinbaş1, İdris Buğra Çerik2, Duygu Yalınbaş Yeter3
1Department of Cardiology, Sivas Numune Hospital, Sivas, Turkey.
概括
内抗VEGF药物可能会影响心脏功能. 这项研究发现,经过三个月的治疗,全球纵向应变 (GLS) 在统计学上显著下降,这表明这些局部治疗的潜在心脏影响.
科学领域:
- 心脏病学 心脏病学
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
背景情况:
- 血管内皮生长因子 (VEGF) 抑制剂在瘤学和眼科中被系统使用.
- 系统性抗VEGF使用与心血管风险有关,但局部应用的影响尚不清楚.
- 研究内抗VEGF的心脏影响至关重要.
研究的目的:
- 评估静脉内抗VEGF药物对左心功能的影响.
- 为了评估心脏机制的变化,使用斑点跟踪回声心脏学.
- 为了确定局部抗VEGF治疗是否会影响心脏功能.
主要方法:
- 一项前性研究,包括44名接受内抗VEGF治疗的患者.
- 在治疗前和三个月后进行的斑点跟踪回声心脏图.
- 全球纵向应变 (GLS) 和区域GLS值的分析.
主要成果:
- 在三个月后观察到全球纵向应变 (GLS) 的统计显著下降.
- 在顶顶四腔,顶顶长轴和顶顶两腔视图中,注意到GLS的显著减少.
- 平均GLS值从基线显著下降到治疗后三个月.
结论:
- 静脉内抗VEGF药物可能会诱导微妙的心脏效应.
- 在局部抗VEGF治疗后,GLS略有下降表明潜在的心脏变化.
- 需要进一步的研究来了解这些发现的临床意义.
关键词:
反对FCEVV的方法抗-VEGFF是一种抗生素.贝瓦西祖马布 (bevacizumab) 是一种药物.心血管疾病的风险.爱心电图 (Ecocardiography) 是一种跟踪斑点的方法.心血管疾病的风险斑点跟踪回声心脏图谱 (echocardiography) 是一种跟踪斑点心脏图谱的方法.更多相关视频
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