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饮食脂肪含量和吸收形状标准饮食通过饥饿回路的值
Ames K Sutton Hickey1, Jordan Becker2, Eva O Karolczak3
1Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Molecular metabolism
|August 31, 2024
概括
高脂肪饮食 (HFD) 的消费导致小鼠标准饮食 (SD) 的值. 这种效应是由摄入后的脂肪反驱动的,而不是味道,这突显了脂肪消化在饮食偏好中的重要性.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究研究 代谢研究
- 营养科学 营养科学
背景情况:
- 在小鼠中,高脂肪饮食 (HFD) 诱导了对标准饮食 (SD) 的偏好.
- 这种由HFD引起的SD值甚至在卡路里剥夺期间也持续存在.
- 导致这种值的具体饮食成分和经验尚不清楚.
研究的目的:
- 调查脂肪含量,成分和感官特性在HFD诱导的SD值中的作用.
- 探索味觉与消化后反对这种现象的贡献.
- 为了确定脂肪吸收对HFD偏好和SD值的影响.
主要方法:
- 对野生型小鼠的HFD和SD的纵向呈现,分析食和代谢参数.
- 在各种饥饿状态下评估急性HFD偏好,包括Agouti相关 (AgRP) 神经元的化学遗传激活.
- 使用短暂受体潜在通道类型M5 (TRPM5) 淘汰赛小鼠来评估味觉和orlistat来抑制脂肪吸收.
主要成果:
- 由HFD引起的SD值取决于脂肪含量,成分和偏好,随着动物脂肪百分比的增加而扩大.
- 消化经验,而不是最初的感官感知,对于值至关重要,正如AgRP神经元活动记录所显示的那样.
- 脂肪味觉 (TRPM5) 没有影响HFD偏好或SD值,但抑制脂肪吸收 (orlistat) 消除了HFD诱导的体重增加和SD值.
结论:
- 消化后的反,特别是脂肪消化,对于表达HFD诱导的SD值至关重要.
- 食脂肪的代谢后果,而不是它的味道,是改变食物偏好的主要驱动因素.
- 了解这些机制对于解决与饮食有关的代谢障碍至关重要.
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