延长,分阶段和自我调节的甲状腺释放与ROS清理相结合,用于类风湿性关节炎治疗的注射水凝
Mingsheng Xu1, Tingting Fu2, Chenhui Zhang2
1School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei 230026, China; CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.
概括
一种新型的可注射水凝可以为类风湿性关节炎 (RA) 治疗提供甲状腺素. 这种先进的水凝提供持续的药物释放,并清除活性氧物种 (ROS),改善动物模型中的治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 导致慢性关节损伤和炎症.
- 甲基 (MTX) 是有效的,但有不良影响,需要更好的交付.
- 目前的水凝缺乏持续和自我调节的药物释放,以及ROS清理.
研究的目的:
- 开发一种可注射的水凝,用于持续和自我调节的MTX的关节内输送.
- 为了将ROS清理能力纳入水凝系统.
- 评估开发的水凝在原诱导性关节炎 (CIA) 鼠标模型中的治疗疗效.
主要方法:
- 使用氨酸和PEG矩阵开发可注射水凝 (MPDANPs/MTX HA-PEG凝).
- 在水凝中同时加载半孔多多巴胺纳米粒子 (MPDANPs) 和MTX.
- 评估MTX释放动力学,ROS清除和CIA大鼠在内关节注射后的抗炎作用.
主要成果:
- MPDANPs/MTX HA-PEG凝显示长时间,分阶段和自我调节的MTX释放.
- 水凝有效地清除了反应性氧物种 (ROS).
- 一次关节内注射在CIA老鼠中显示出强大的抗炎作用.
结论:
- 开发的MPDANPs/MTX HA-PEG凝为RA提供了一个先进的治疗策略.
- 液凝的持续药物释放和ROS清除增强了治疗疗效.
- 这种创新方法有望改善RA患者的治疗结果.
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