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在药品样本中对局部麻醉剂普罗卡因进行电位测量测定

Oguz Özbek¹, Onur Cem Altunoluk²

¹Tokat Gaziosmanpaşa University, Faculty of Science and Arts, Department of Molecular Biology and Genetics, 60250, Tokat, Turkey.

Analytical biochemistry

|August 31, 2024

概括

开发了一种新型的电位计传感器,采用甲 (Pr) - 四乙酸 (TPB) 离子对,用于准确地确定制药样本中的甲. 这种新的传感器提供了低检测极限和快速响应时间,在现实应用中被证明是有效的.

科学领域:

分析化学分析化学
电化学电化学电化学
材料科学材料科学材料科学

背景情况:

准确量化局部麻醉剂,如普罗卡因在制药分析中至关重要.
现有的普罗卡因测定方法可能缺乏灵敏度,速度或复杂矩阵中的适用性.
选择性和高效的电位计传感器的开发是一个活跃的研究领域.

研究的目的:

开发和表征一种用于确定普罗卡因的新型电位计传感器.
优化传感器组合以提高性能,包括灵敏度和响应时间.
评估传感器在药品注射样本中分析普罗卡因的适用性.

主要方法:

合成作为活性传感器材料的普洛卡因 (Pr) - 四乙酸 (TPB) 离子对.
使用Pr-TPB,聚乙烯化物 (PVC) 和o-nitrophenyloctyl以太 (o-NPOE) 在不同比例的电位传感器的制造.
性能评估包括电位测响应,线性,检测极限,响应时间和pH稳定性.
通过在药物注射样本中分析普罗卡因来验证传感器的有效性.

主要成果:

发现最佳的传感器组成是Pr-TPB:PVC:o-NPOE,其比例为6.0:32.0:62.0 (w/w %).
开发的传感器表现出接近Nernstian的行为 (54.1 ± 3.3 mV/十年) 具有较低的检测极限 (3.18 × 10−5 mol L−1).
传感器显示出快速响应时间 (<10秒),广泛的pH工作范围,并在注射样本中成功确定了高恢复率的普罗卡因.

结论:

已成功开发出一种高效的潜在度传感器来测定普罗卡因.
传感器的性能特性使其成为含有普罗卡因的药品质量控制的宝贵工具.
开发的传感器提供了一种灵敏,快速和可靠的方法,用于在真实样本中分析普罗卡因.

关键词:

离子对离子对局部麻醉剂局部麻醉剂电位计学是指电位计学的方法.普罗卡因 (Procaine) 是一种蛋白质.传感器传感器传感器

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