正念冥想和安慰剂调节明显的多变量神经特征,以减少疼痛
Gabriel Riegner1, Jon Dean1, Tor D Wager2
1Department of Anesthesiology, University of California San Diego, La Jolla, California.
Biological psychiatry
|August 31, 2024
概括
正念冥想和安慰剂治疗通过不同的大脑机制减少疼痛. 与安慰剂干预相比,正念冥想通过参与独特的神经通路显著降低了疼痛强度和不愉快感.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 心理学 心理学 心理学
背景情况:
- 疼痛感知受到认知情感状态和期望的影响,而不仅仅是感觉.
- 据信,安慰剂反应通过与活性疗法共享的机制来减少疼痛.
- 专注于非判断性意识的正念冥想,此前被认为通过类似安慰剂的机制运作.
研究的目的:
- 为了调查正念冥想是否与安慰剂干预措施相比,在减轻疼痛方面涉及不同的神经机制.
- 使用多变量模式分析,将正念冥想的基于大脑的疼痛特征与安慰剂和假正念区分开来.
主要方法:
- 两项随机临床试验使用多变量模式分析 (MPA) 疼痛特征.
- 参与者通过有害热和视觉模拟秤进行了心理物理疼痛测试.
- 在干预后使用功能磁共振成像 (fMRI) 技术 (BOLD和基于 perfusion)
主要成果:
- 与安慰剂奶油相比,正念冥想显示了MPA疼痛特征的双重分离.
- 正念冥想显著降低了疼痛强度,不愉快感和相关的神经特征,比安慰剂,假正念或控制.
- 而安慰剂奶油干预特别减少了基于安慰剂的神经特征.
结论:
- 正念冥想和安慰剂干预措施涉及不同的神经疼痛信号.
- 这些发现揭示了这些方法如何调节大脑以减少疼痛的细粒度差异.
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