从脂质分子的角度剖析per-和多醇基物质 (PFAS) 与功能之间的关联
Yi-Ran Chen1, Shao-Bin Lin2, Jia-Yun Lv3
1Institute of Public Health, Guangzhou Medical University & Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China; School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Environmental pollution (Barking, Essex : 1987)
|August 31, 2024
概括
和多醇基物质 (PFAS) 混合物与尿酸水平的增加有关,尿酸是功能标志物. 特定的脂质分子调解了这种关联,突出了PFAS毒性的潜在机制.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 代谢学 代谢学 代谢学
背景情况:
- 和多基物质 (PFAS) 暴露很普遍,并与不良健康结果有关.
- 脂质代谢对功能至关重要,但PFAS混合物对这种相互作用的影响尚未完全理解.
- 现有的研究尚未全面阐明PFAS影响脏健康的机制.
研究的目的:
- 调查PFAS混合物对功能指数的整体影响.
- 通过分析脂质谱来剖析PFAS诱导的功能障碍的机制.
- 检查特定脂类子类与功能之间的关联.
主要方法:
- 在278名男性的血液中量化PFAS水平和功能指数.
- 利用代谢分析识别了332个脂质分子.
- 应用基于量子的g计算和回归模型来评估PFAS混合物效应和脂质关联.
主要成果:
- PFAS混合物与尿酸 (UA) 水平升高有关.
- perfluorooctanoic 酸 (PFOA) 显示与UA和高尿路血症几率的积极关联.
- 没有发现PFAS和估计的淋巴细胞过率 (eGFR) 之间有显著的关联.
- 七个脂质分子调解了PFOA-UA关联,以及与功能指数相关的特定脂质子类.
结论:
- PFAS混合物,特别是PFOA,与功能标记物发生变化有关,主要是尿酸升高.
- 脂质代谢在PFAS的毒性中起着调解作用.
- 研究结果表明,特定的脂类子类是潜在的生物标志物和目标,以了解PFAS诱导的损伤.
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