复合精子生成药丸的毒性研究:急性毒性和亚急性毒性
Ruyi Feng1, Yanlu Li1, Junxia Ma1
1College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun, 130118, China.
Journal of ethnopharmacology
|August 31, 2024
概括
精子发育药丸 (SP) 是一种无毒的传统中医药,经过急性和亚急性毒性研究证实. 这项研究支持其安全的临床使用和剂量建立.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 传统中国医药 传统中国医药
背景情况:
- 精子生成药丸 (SP) 是一种广泛使用的临床制剂,享有十多年的声誉.
- 缺乏广泛的研究阻碍了对其安全性概况和潜在的临床限制的理解.
研究的目的:
- 通过全面的急性和亚急性毒性评估,评估精子生成药丸 (SP) 的安全性.
- 识别SP中的活性化合物和无机元素,以支持毒理学评估.
主要方法:
- 化学分析使用LC-MS用于活性化合物和ICP-MS用于无机元素.
- 在不同剂量的小鼠体内急性毒性测试 (14天) 和亚急性毒性测试 (28天).
- 血液参数,肝/功能,糖脂代谢,器官系数和组织学检查 (HE染色) 的全面分析.
主要成果:
- 确定了包括黄类 (Quercetin,Kaempferol) 和类在内的关键活性化合物.
- 在急性毒性测试中没有观察到副作用或中毒症状.
- 亚急性测试显示了良好的状态,在最高剂量 (30g/kg) 下降了体重/食物摄入量,增强了脏淋巴细胞成熟和免疫力,对血液,肝脏或功能没有显著的毒性影响.
结论:
- 精子发育药丸 (SP) 是无毒的,含有显著的黄类和类活性成分.
- 这些发现为SP的临床应用提供了强有力的安全基础,指导剂量和毒性监测.
- 这项研究为未来对SP的临床试验奠定了理论基础.
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