相关实验视频

Updated: Jul 1, 2026

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

关节内自身蛋白质溶液对膝关节骨关节炎症状的影响

Marla Ross¹, Yushy Zhou^1,2,3, Michael English¹

¹Orthopaedic Surgery, Whangārei Hospital, Whangārei, New Zealand.

The bone & joint journal

|August 31, 2024

概括

自生蛋白溶液 (APS) 注射与盐水相比,没有改善膝关节关节炎症状. 接受APS治疗的患者在12个月后感到更严重的疼痛,这表明这种膝关节OA治疗没有益处.

科学领域:

整形外科整形外科整形外科
再生医学是一种再生医学.
生物制剂生物制剂生物制剂

背景情况:

膝关节关节炎 (OA) 涉及慢性炎症和软骨退化.
包括自身蛋白溶液 (APS) 在内的关节内疗法正在探索非手术性OA治疗.
APS是从患者的血液中衍生出来的,集中了抗炎细胞因子.

研究的目的:

为了评估nSTRIDE的疗效,一种特定的APS内关节注射,与中度膝关节OA患者的盐水相比.
为了比较患者报告的结果,包括APS和安慰剂组之间的WOMAC,KOOS和VAS得分.

主要方法:

一个平行,双盲,安慰剂控制的随机试验.
40名中度膝关节骨质炎患者 (Kellgren-Lawrence 2~3级) 接受了nSTRIDE或盐水注射.
主要结局:12个月后的WOMAC总分. 二次结局:WOMAC,KOOS和VAS分数在3,6和12个月.

主要成果:

在12个月的WOMAC总分数中,nSTRIDE和盐酸组之间没有显著差异.
在所有随访时间点中,没有观察到WOMAC或KOOS得分的显著差异.
在12个月后,VAS得分表明nSTRIDE组的疼痛 (休息和最严重) 与盐水相比明显更糟.

结论:

与盐水相比,nSTRIDE (APS) 注射对中度膝关节OA的WOMAC或KOOS得分没有显著改善.
在治疗后12个月,APS注射与明显更糟糕的疼痛结果有关.
这项研究在两组治疗中都没有发现任何不良事件.

更多相关视频

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

Published on: September 29, 2018

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment

Published on: April 26, 2024

相关概念视频

Blood and Nerve Supply to the Bones

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...

Knee Joint

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...

Herniated Intervertebral Disc l: Introduction

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...