根据对元分析进行的系统性审查,C型肝炎病毒感染与蛋白尿有关
Fabrizio Fabrizi1, Maria F Donato2, Luca Nardelli3
1Division of Nephrology, Dialysis, and Kidney Transplant, Foundation IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
Nefrologia
|August 31, 2024
概括
肝炎C病毒 (HCV) 感染与一般人群中蛋白尿风险较高有关. 这一系统性审查发现了显著的关联,促使推查HCV暴露个体蛋白尿症.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 肝炎C病毒 (HCV) 感染和慢性病 (CKD) 是全球重要的健康问题.
- 关于HCV作为CKD发展和进展的风险因素的作用,存在相互矛盾的证据.
研究的目的:
- 系统地审查和元分析HCV血清状况与成人一般人群中蛋白尿风险之间的关联.
主要方法:
- 对已发表的文献进行了系统的审查.
- 对23项研究 (n=198,967) 的数据进行了随机效应模型元分析.
- 分析根据研究设计 (横截面,纵向) 和尿蛋白测量方法进行了分层分析.
主要成果:
- 在横截面 (OR, 1.47) 和纵向研究 (HR, 1.79) 中,发现HCV感染与蛋白尿风险增加之间存在显著的关联.
- 超回归表明,HCV暴露的男性中蛋白尿的患病率较高.
- 使用尿蛋白/肌素比率的研究表明,在HCV阳性个体中,蛋白尿的聚合OR为1.64,没有显著的异质性.
结论:
- 在一般人群中,HCV感染与蛋白尿风险增加之间存在显著的关系.
- 对潜在的生物机制进行进一步研究是有必要的.
- 在所有暴露于HCV的患者中,建议对蛋白尿进行查.
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