在仿真抗原受体 (CAR) T细胞中使用的CD28链在全球性疾病中表现出局部结构和构造性交换

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Varvara Folimonova1, Xiang Chen1, Hitendra Negi1

  • 1Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

Communications biology
|August 31, 2024
PubMed
概括

研究人员在癌症治疗中研究了CD28 CAR链 (CD28H) 结构. 生物物理方法揭示了短暂的局部结构,如螺旋,有助于灵活性,这可能会改善仿真抗原受体 (CAR) T 细胞治疗设计.

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