塑料诱导的尿路疾病和功能障碍:一个范围审查
Liam O'Callaghan1, Matthew Olsen1, Lotti Tajouri1,2,3
1Faculty of Health Sciences and Medicine, Bond University, Robina, QLD, Australia.
Journal of exposure science & environmental epidemiology
|August 31, 2024
概括
微塑料和纳米塑料 (MNP) 越来越多地出现在人体泌尿道中,研究表明细胞毒性作用和炎症. 这挑战了以前的健康评估,并迫切需要重新评估MNP风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 世卫组织2019年的一份报告发现,饮用水中的微塑料不构成健康威胁.
- 新兴研究表明,塑料在器官中的存在具有有害影响.
研究的目的:
- 审查关于微塑料和纳米塑料 (MNP) 在人尿道中的存在和影响的文献.
- 评估该系统中MNP污染对公共卫生的影响.
主要方法:
- 根据约翰娜·布里格斯研究所的建议进行了范围审查.
- 在五个数据库 (PubMed,SCOPUS,CINAHL,Web of Science,EMBASE) 和灰色文献中进行系统搜索.
主要成果:
- 确定了18个物品;六个确认MNP在尿路中的存在 (脏,尿液,膀癌样本).
- 十二篇文章显示MNP诱导细胞毒性,炎症,减少细胞活力,并改变了尿路细胞系中的MAPK信号传递.
结论:
- 尿路中的MNP可能会对膀疾病和功能障碍造成健康风险.
- 世卫组织对MNP安全性的立场需要根据当前证据紧急重新评估.
- 进一步的研究和政策制定对于解决MNP污染问题至关重要.
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