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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
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RNA Splicing01:32

RNA Splicing

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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相关实验视频

Updated: Jun 14, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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膀癌:非编码RNA和外体非编码RNA.

Jingang Zhao1, Yangyang Ma1, Xiaodong Zheng2

  • 1Department of Urology, Hangzhou Mingzhou Hospital, Hangzhou, 311215, Zhe'jiang, China.

Functional & integrative genomics
|August 31, 2024
PubMed
概括

非编码RNAs (ncRNAs) 是膀癌 (BCa) 发展中的关键参与者. 外体的ncRNA显示出新型BCa诊断和治疗的前景.

关键词:
膀癌是一种癌症.这是循环RNARNA.异构体是什么? 异构体是什么? 外构体是什么?长的非编码RNA是什么?这是一个微型RNA.没有编码的RNAs.

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An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
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相关实验视频

Last Updated: Jun 14, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
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Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 膀癌 (BCa) 是一种普遍存在的恶性瘤,具有重大的全球健康影响.
  • 了解BCa的分子基础对于开发新的诊断和治疗策略至关重要.
  • 非编码RNAs (ncRNAs),包括microRNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs),越来越多地被认为是BCa中的角色.

研究的目的:

  • 审查各种ncRNAs在膀癌发病过程中的参与.
  • 突出了BCa.中外体ncRNAs的重要性.
  • 探索外体的潜力作为BCa.在BCa.在BCa.在BCa.在BCa.在BCa.在BCa.在BCa.

主要方法:

  • 文献综述侧重于膀癌中的ncRNA和外体.
  • 对研究不同ncRNA类型在BCa中的作用的研究进行分析.
  • 对BCa.中的外体生物发生,载荷和功能的研究进行了审查.

主要成果:

  • 许多ncRNA与膀癌的进展和表现有关.
  • 从各种细胞类型中衍生出来的外体内含有与BCa.相关的多种ncRNAs.
  • 外体ncRNAs显示出作为BCa检测和预后的生物标志物的潜力.
  • 外体的脂质双层结构使它们适合向癌症治疗.

结论:

  • ncRNAs在膀癌的发病过程中起着至关重要的作用.
  • 外体ncRNAs代表了非侵入性膀癌诊断和预后的有希望的途径.
  • 外体具有作为膀癌治疗有效药物输送系统的潜力.