将异常脂肪分布与HFpEF和腹功能障碍联系起来:观察性研究的系统审查,元分析和元回归
Zhenyue Fu1,2, Yajiao Wang1, Yuxin Wang1
1Department of General Internal Medicine, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Lipids in health and disease
|August 31, 2024
概括
异常的脂肪分布与心脏扩张性功能障碍有关,这种情况通常与肥胖有关. 这一系统性审查证实了多余脂肪与腹功能障碍风险之间的显著关联.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 全球肥胖率是一个重大的健康挑战.
- 肥胖与心脏扩张功能障碍和心脏衰竭与保存的喷射分数 (HFpEF) 有关.
- 不正常的脂肪分布可能会增加心脏扩张性功能障碍的风险.
研究的目的:
- 系统地审查和阐明异常脂肪分布和心脏扩张功能障碍之间的相关性.
- 在全球肥胖趋势的背景下分析这种关联.
主要方法:
- 按照柯克兰手册和PRISMA 2020指南进行系统的文献审查.
- 在PubMed,Embase和Web of Science中搜索相关研究.
- 用标准化平均差异 (SMD) 和费舍尔的z值对63项研究 (43113名参与者) 的元分析.
主要成果:
- 患有心脏扩张功能障碍的人群中,异常脂肪分布显著增加 (SMD 0.88).
- 脊心脂肪组织显示出强烈的关联 (SMD 0.99).
- 发现异常脂肪分布和心脏扩张性功能障碍风险之间存在显著的相关性,特别是在超重和肥胖人群中.
结论:
- 异常的脂肪分布与患心脏扩张功能障碍的风险增加有显著关联.
- 研究结果强调了管理脂肪分布在心血管健康中的重要性.
更多相关视频
03:42Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
Published on: March 29, 2024
1.4K
11:04Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
Published on: September 1, 2014
11.1K
相关概念视频
Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Heart Failure Drugs: Diuretics
352
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
352
Imaging Studies for Cardiovascular System III: X-Ray
160
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
160
Cardiovascular System Abnormal Findings II: Auscultation
111
Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
Abnormal Heart Sounds
Gallops:
111
