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在发育和性脑病变中脑视力障碍的患病率:系统性审查协议
Martina Giorgia Perinelli1, Megan Abbott2,3, Ganna Balagura1
1Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, IRCCS Istituto "G. Gaslini", Via Gaslini 5, 16148, Genova, Italy.
Systematic reviews
|August 31, 2024
概括
这一系统性审查将确定发育性和性脑病变 (DEE) 患者中脑视力障碍 (CVI) 的患病率. 了解DEE患者中CVI患病率对于早期检测和干预策略至关重要.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 遗传学 是一个遗传学.
背景情况:
- 发育性和性脑病变 (DEE) 是一种严重的神经系统疾病,通常与遗传原因有关.
- 患有DEE的患者经常经历大脑视觉障碍 (CVI),这是一个中心视觉功能障碍.
- 在DEE患者中CVI的患病率仍然未知,需要对现有数据进行定量综合.
研究的目的:
- 进行系统性审查和元分析,以确定发育性和性脑病变 (DEE) 患者中脑视力障碍 (CVI) 的患病率.
- 提供现有数据的定量综合,以了解CVI在这个人群中的程度.
- 为未来的研究提供信息,并指导在DEE患者中早期识别和预防CVI策略的开发.
主要方法:
- 遵守PRISMA-P和JBI证据综合手册的协议.
- 在多个数据库 (MEDLINE,EMBASE,Scopus等) 中进行全面的文献搜索. ) 的情况.
- 使用CoCoPop框架进行系统审查和元分析,评估偏见风险,异质性 (Cochrane Q) 和证据质量 (GRADE).
主要成果:
- 在系统性审查和元分析完成后,该部分将被填写.
结论:
- 本协议概述了一个全面的系统审查和元分析,以解决关于DEE患者中CVI患病率的知识差距.
- 这项研究是新的,因为它特别关注CVI和DEE之间的流行病学关系.
- 预期的结果将对理解CVI在DEE的范围至关重要,指导未来的研究,并为临床干预提供信息.
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