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Updated: Jun 14, 2025

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Published on: January 31, 2018

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PARP1-TRIM44-MRN循环决定了对 PARP 抑制剂的反应

Yonghyeon Kim1, Sunwoo Min1,2, Soyeon Kim3

  • 1Department of Biochemistry, Ajou University School of Medicine, Suwon 16499, Republic of Korea.

Nucleic acids research
|September 1, 2024
PubMed
概括

研究人员确定TRIM44是DNA修复中的关键媒介. 这种蛋白质将PARP1与ATM通路联系起来,影响同源重组修复 (HRR),并可能增强PARP抑制剂的有效性.

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