和雄激素受体与前列腺切除术结果之间是否存在关系?
Bárbara Vieira Lima Aguiar Melão1, Sabrina Thalita Dos Reis Faria2, Kátia Ramos Moreira Leite2
1Division of Urology, University of São Paulo Medical School, São Paulo, Brazil.
The Canadian journal of urology
|September 1, 2024
概括
在接受前列腺癌手术的男性中,低水平与更差的勃起功能恢复和更高的生化复发率相关. 更高的雄激素受体表达也被注意到在男性低丸激素.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 前列腺癌的结果很难预测,即使使用现有的生化复发 (BCR) 预测器.
- 丸激素在局部性前列腺癌中的作用仍然不确定,与其在晚期已知的作用不同.
研究的目的:
- 研究手术前丸激素水平和雄激素受体 (AR) 表达与激进逆管前列腺切除术 (RRP) 后患者的瘤和功能结果之间的关系.
主要方法:
- 对212名接受RRP并至少进行两次手术前总测量的患者进行了回顾性分析.
- 基于丸激素水平的瘤和功能结果的比较.
- 在生物存储库的组织样本中评估AR和AR-V7表达.
主要成果:
- 32名患者 (15.1%) 的丸激素水平较低.
- 低丸激素与24个月后更低的勃起功能恢复率相关 (53.1%与71.7%,p=0.037).
- 低丸激素患者的BCR率较高 (21.9%对9.4%,p=0.041) 和ISUP等级更高.
结论:
- 术前较低的丸激素水平与勃起功能恢复的减弱和RRP后BCR率的增加有关.
- 在低丸激素 (<300 ng/dL) 的患者中观察到更高的AR表达,但这与不同的BCR率无关.
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