用MitraClip治疗心力衰竭和中度至重度功能性部吐的症状患者住院治疗:来自RESHAPE-HF2的见解
Piotr Ponikowski1, Tim Friede2, Ralph Stephan von Bardeleben3
1Institute of Heart Diseases, Medical University and University Hospital, Wroclaw, Poland.
Journal of the American College of Cardiology
|September 1, 2024
概括
mitra transcatheter 边缘到边缘修复 (M-TEER) 显著减少住院治疗,并改善了功能性 mitra 吐心力衰竭患者的治疗结果. 该疗法对那些最近先前住院治疗的人特别有好处.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 心脏衰竭管理的管理
背景情况:
- 在有症状的心力衰竭 (HF) 患者中,对功能性心脏反 (FMR) 的 mitra transcatheter 边缘到边缘修复 (M-TEER) 的随机试验存在相互矛盾的结果.
- 对M-TEER的最佳患者选择仍然是一个研究领域.
研究的目的:
- 评估M-TEER对症状性FMR和HF患者住院率的影响.
- 具体分析M-TEER对最近有或没有HF住院的患者的影响.
主要方法:
- 从RESHAPE-HF2试验 (n=333) 中预先规定的数据分析,重点关注住院率.
- 接受M-TEER和仅接受最佳医疗治疗的患者之间的结局的比较.
- 在随机化前12个月内有HF住院病史的患者的子组分析.
主要成果:
- 在24个月内,M-TEER显著降低了心血管死亡或HF住院的复合情况 (HR:0.65).
- M-TEER降低了经常性心血管住院率 (RR:0.75) 和所有原因死亡率 (RR:0.74).
- 接受M-TEER治疗的患者经历了较少的死亡或HF住院日数,并改善了NYHA功能类.
结论:
- 除了指导方针导向的医疗治疗外,M-TEER应考虑在有症状的HF患者中度至重度的FMR.
- M-TEER的好处在最近有HF住院病史的患者中尤为明显.
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