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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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建立和评估癌症缓解症小鼠模型的协议.

Zhijun Zhou1, Jingxuan Yang1, Mingyang Liu1

  • 1Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

STAR protocols
|September 1, 2024
PubMed
概括
此摘要是机器生成的。

这项研究详细介绍了一项创建和评估癌症缓解症小鼠模型的协议. 这些模型有助于研究人员研究患者中缓冲症的临床特征.

关键词:
癌症 癌症 癌症 癌症细胞生物学 细胞生物学细胞培养培养的细胞培养.健康科学 卫生科学 卫生科学代谢过程中的代谢.模型生物模型生物系统生物学 系统生物学

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科学领域:

  • 在瘤学瘤学.
  • 动物模型 动物模型
  • 身体生理学 身体生理学

背景情况:

  • 癌症缓解症显著影响患者的健康和生活质量.
  • 迫切需要可靠的小鼠模型,能够准确地反映人类癌症缓解症.
  • 目前的模型需要标准化的协议来进行一致的评估.

研究的目的:

  • 为建立和评估癌症缓解症小鼠模型提出一个全面的协议.
  • 为瘤细胞准备,注射和外科手术程序提供详细的步骤.
  • 在已建立的小鼠模型中概述评估缓解症指标的关键方法.

主要方法:

  • 在小鼠中进行瘤细胞注射的详细外科手术程序.
  • 握力测试用于评估肌肉功能.
  • 组织采集和组织分析用于测量肌肉横截面积.

主要成果:

  • 成功建立了癌症缓解症小鼠模型的成功建立.
  • 掌握强度测试在评估肌肉损耗方面的证明有效性.
  • 通过横截面面积分析对肌肉组织变化的量化数据.

结论:

  • 提出的协议使得可靠地创建和评估癌症缓解症小鼠模型.
  • 这些模型是研究癌症缓解症机制和测试干预措施的宝贵工具.
  • 标准化的评估方法确保了研究的可复制性和可比性.