SARS-CoV-2 对精液参数的可逆影响
Meritxell Jodar1,2, Yasmina Barral3, Marina Leiva1
1Molecular Biology of Reproduction and Development Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Fundació de Recerca Clínic Barcelona, Universitat de Barcelona, Barcelona, Spain.
Systems biology in reproductive medicine
|September 1, 2024
概括
感染SARS-CoV-2可能会暂时降低不孕男性的精液量和精子运动率,特别是未接种疫苗的人和感染阿尔法菌株的人. 精液参数通常在感染后的一次精子生成周期内恢复.
科学领域:
- 生殖医学 生殖医学
- 传染性疾病 传染性疾病
- 安德罗学与人类学
背景情况:
- SARS-CoV-2 流行病引起了人们对男性潜在的长期生殖健康影响的担忧.
- 了解SARS-CoV-2对男性生育能力的影响对于公共卫生和生殖咨询至关重要.
研究的目的:
- 研究SARS-CoV-2感染对不孕男性精液参数的影响.
- 为了比较感染前和感染后的精液质量,考虑疫苗接种状态和病毒菌株等因素.
主要方法:
- 追溯研究设计,比较患有和没有SARS-CoV-2感染的不孕男性.
- 用威尔科克森试验和一般线性回归分析精液参数,包括体积和运动率.
- 基于疫苗接种状态和SARS-CoV-2菌株 (α变种) 的数据分层.
主要成果:
- SARS-CoV-2 感染与精液量 (p < 0.005) 的有害影响有关.
- 减少的精液量主要在感染后的第一个精子生成周期和未接种疫苗的患者中观察到.
- 在感染阿尔法SARS-CoV-2菌株 (p <0.05) 的患者中检测到渐进性运动的改变.
结论:
- 在不孕男性中,SARS-CoV-2感染对精液量和精子运动有有限的,暂时的影响.
- 精液参数通常在一个精子生成周期内恢复到感染前的水平.
- 疫苗接种状态和特定的病毒株可能会影响这些影响的程度.
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