铜离子协调介导的分子印记电化学传感器用于识别和比度检测利多卡因
Yiwei Liu1, Qiong Ding2, Kai Hu2
1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China; Biogas Institute of Ministry of Agriculture and Rural Affairs, Chengdu, 610041, Sichuan Province, PR China; Key Laboratory of Development and Application of Rural Renewable Energy, Ministry of Agriculture and Rural Affairs, Chengdu, 610041, Sichuan Province, PR China.
Talanta
|September 1, 2024
概括
使用铜协调分子印记聚合物 (MIPs) 的新型电化学传感器提高了利多卡因的检测. 这种金属协调策略提高了可靠传感应用的灵敏度和选择性.
科学领域:
- 电化学 电化学 电化学
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 分子印记聚合物 (MIP) 是传感中关键的人工识别元素.
- 现有的MIP电化学传感器面临着有限的亲和力和不受控制的状态变化的挑战.
- 金属协调相互作用为提高MIP传感器性能提供了一个有希望的策略.
研究的目的:
- 开发一种新的MIP电化学传感器,用于利多卡因 (LC) 识别和比度检测.
- 利用金属协调来提高MIP识别站点的亲和力和稳定性.
- 为提高准确性,建立使用化铜离子的比度检测策略.
主要方法:
- 在生物质碳改性玻璃碳电极上沉积Cu-协调MIP薄膜电极的制造.
- 在MIP合成过程中利用Cu2+离子作为利多卡因固定.
- 使用Cu2+和LC之间的金属协调来进行特定的分子识别.
- 实施基于LC和铜离子的峰值电流比率的比度检测策略.
主要成果:
- 该传感器表现出高选择性,灵敏性,可重复性和抗干扰能力.
- 在0.0082.5μmol L-1 (R2 = 0.9951) 范围内观察到峰值电流比率和LC度之间的线性关系.
- 实现了1.9nmol L-1 (S/N = 3) 的低检测极限.
- 在分析人类血清和制药样本时获得了令人满意的结果.
结论:
- 开发的Cu-协调MIP电化学传感器有效地解决了传统MIP传感器的局限性.
- 金属协调策略显著提高了利多卡因的识别和检测.
- 分量测量方法为复杂矩阵中的利多卡因量化提供了一种可靠和敏感的方法.
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