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分析剂量计算方法的可行性,用于Au-198手腕治疗

Kengo Ito¹, Yojiro Ishikawa¹, Satoshi Teramura¹

¹Division of Radiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 983-8536, Japan.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

|September 1, 2024

概括

CT_only方法准确计算了198个Au种子剂量,在不均的组织中表现优于TG43. 这种基于计算机断层扫描 (CT) 的分析方法与蒙特卡洛模拟相比,大大减少了计算时间.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
放射治疗剂量计放射治疗剂量计

背景情况:

准确的剂量计算对于有效的支臂治疗至关重要.
198种Au种子需要精确的剂量测量来治疗口腔癌.
像TG43这样的传统方法可能无法完全解释组织不均性和分散.

研究的目的:

评估基于CT的分析剂量计算方法 (CT_anly) 对198种Au种子的有效性.
要将CT_anly与黄金标准蒙特卡洛 (MC) 方法和TG43方法进行比较.
为了评估虚拟幻影和患者CT图像模拟口腔癌的性能.

主要方法:

将CT_anly,MC和TG43方法应用于虚拟水和异质幻象 (包括脂肪,肺,骨和).
利用患者CT图像与模拟的Au种子和板.
进行了马分析 (2%/2-mm值) 来比较剂量分布和测量计算持续时间.

主要成果:

CT_anly显示了与水幽灵中的MC相似的剂量分布.
对于异质的幻影和患者图像,CT_anly提高了马传递率,并产生了MC类似的剂量分布.
计算时间从天 (MC) 减少到分钟 (CT).

结论:

CT_anly方法对于¹⁹⁸Au种子剂量计算是有效和准确的.
与MC相比,CT_anly可以显著减少计算时间.
这种基于CT的方法在复杂的解剖区域中有望改善支臂疗法剂量.

关键词:

在 Au-grain 中使用.澳大利亚198198年澳大利亚支臂疗法是一种手臂疗法.剂量计算剂量计算

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