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七种药用活性化合物的生态毒理学研究:混合物效应和环境风险评估

Carolina Rodrigues Dos Santos¹, Guilherme Otávio Rosa E Silva¹, Camila de Figueiredo Valias²

¹Department of Sanitary and Environmental Engineering, Universidade Federal de Minas Gerais, 6627, Antônio Carlos Avenue, Campus Pampulha, 31270-901, Belo Horizonte, MG, Brazil.

Aquatic toxicology (Amsterdam, Netherlands)

|September 1, 2024

概括

这项研究表明,制药化合物 (PhAC) 的混合物可能比预期的更有毒,构成重大环境风险. 先进的废水处理对于减轻这些新出现的污染物的生态影响至关重要.

科学领域:

环境化学环境化学
生态毒理学生态毒理学
水生毒理学水生毒理学

背景情况:

药物活性化合物 (PhAC) 在水生环境中被检测到,由于潜在的不良影响,引发了环境问题.
对于许多PhAC,特别是混合物中的生态毒理学数据缺乏,这阻碍了准确的风险评估.
废水排放不断将PhAC和其他微污染物引入水体,导致复杂的混合物相互作用.

研究的目的:

评估七种PhAC单独和二进制/三进制混合物中的生态毒性.
将实验性毒性数据与度添加 (CA) 和独立作用 (IA) 模型进行比较.
在水生生态系统中对选定的PhAC进行环境风险评估.

主要方法:

使用Aliivibrio fischeri生物发光抑制试验对七种PhAC进行毒性测试.
个人,二元和三元PhAC混合物的评估.
观察到的毒性与CA和IA预测模型的比较.
基于测量和预测的环境度进行的环境风险评估.

主要成果:

费诺纤维酸 (FEN),洛拉塔丁 (LOR) 和 (KET) 的毒性最高 (EC50值分别为0.32,6.15和36.8毫克L-1).
在混合物 (FEN + LOR,KET + LOR,KET + FEN + LOR) 中观察到协同作用的毒性作用,这表明CA和IA模型可能低估了这种作用.
在几个地点发现了KET (藻类) 和LOR/17α-乙烯基 (EE2) (甲类动物,鱼类) 的高环境风险.

结论:

PhAC混合物可以表现出协同毒性,超过标准模型的预测.
烯和洛拉塔丁对环境构成重大风险,因此需要在废水处理中提取的速度很高.
对PhAC相互作用的进一步研究和全面的风险评估对于保护水生生态系统至关重要.

关键词:

艾利维布里奥·菲舍里 (Aliivibrio fischeri) 是一个鱼类生物.度加值模型的模型.独立行动模式的独立行动模式协同作用协同作用协同作用有毒性有毒性

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