在神经髓炎光学谱系障碍中复发独立的疾病活性:系统性审查
Masoud Etemadifar1, Seyyed-Ali Alaei2, Tetsuya Akaishi3
1School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Multiple sclerosis and related disorders
|September 1, 2024
概括
在神经脊髓炎光学谱障碍 (NMOSD) 中存在复发独立疾病活动 (RIDA),即使在没有复发的时期,也主要影响视觉系统. 需要进一步的研究来制定RIDA诊断和治疗指南.
科学领域:
- 神经免疫学 神经免疫学
- 眼科医生 眼科 眼科
- 神经学 神经学
背景情况:
- 神经omyelitis光学谱系障碍 (NMOSD) 是一种神经炎症状况,通常通过解决复发相关恶化 (RAW) 来管理.
- 新出现的证据凸显了NMOSD患者中复发独立疾病活动 (RIDA) 的意义,表明疾病进展独立于复发.
研究的目的:
- 系统地审查和综合有关神经omyelitis光学谱障碍 (NMOSD) 中复发独立疾病活动 (RIDA) 的现有证据.
- 在NMOSD患者中确定RIDA在不同系统中的患病率和表现.
主要方法:
- 在Embase,PubMed,Scopus和Web of Science进行了系统的文献搜索,直到2023年12月.
- 包括报告NMOSD患者RIDA证据的研究,数据提取遵循PRISMA指南.
- 关于PROSPERO的注册协议 (ID = CRD42023492352) 确保了方法的严格性.
主要成果:
- 该审查包括38项研究,包括1881名NMOSD患者,其中90.6%的检测结果为AQP4-IgG阳性.
- 在23项研究中报告了眼部发现 (例如,视网膜层稀薄,VEP异常),在13项研究中报告了MRI发现 (损伤,缩).
- 在五项研究中,血清和脑脊液分析显示sGFAP和sNFL的升高,活检/尸检表明无复发患者的炎症.
- 视觉系统成为RIDA的主要部位,涉及像穆勒细胞这样的视网膜质细胞.
结论:
- 这一系统性审查强调了神经omyelitis光学谱障碍 (NMOSD) 中复发独立疾病活动 (RIDA) 的存在和影响.
- 视觉系统是RIDA影响的关键区域,即使没有复发.
- 在NMOSD中建立RIDA的诊断和治疗指南至关重要,需要进一步研究以获得强有力的证据.
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