儿科瘤治疗和呈现的差异:一项全国性研究
Rahul K Sharma1, Shreyas G Krishnapura2, John Ceremsak1
1Department of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
International journal of pediatric otorhinolaryngology
|September 1, 2024
概括
儿科状腺癌在瘤大小和治疗方面存在种族差异,西班牙裔患者更有可能接受面部神经牺牲. 解决这些不平等问题对于改善代表性不足的群体的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 儿科医学 儿科医学
- 健康差距 研究 研究 研究 研究
背景情况:
- 腺恶性瘤是罕见的,但是儿童发病和死亡的重要原因.
- 现有的研究还没有充分确定小儿癌的呈现,治疗和生存率的差异.
- 了解护理中的差异对于改善历史上服务不足的人群的结果至关重要.
研究的目的:
- 调查儿童腺恶性瘤的呈现,治疗和生存的种族和民族差异.
- 为了确定不良结果的预测因素,包括瘤大小,阶段,以及需要面部神经牺牲的需要,在不同的种族和民族群体.
主要方法:
- 使用监测,流行病学和最终结果 (SEER) 计划数据库进行回顾性队列研究.
- 分析了在2000年至2019年期间被诊断患有腺恶性瘤的149名儿科患者.
- 使用卡普兰-梅尔生存分析和多变量后勤回归来评估基于种族/种族,收入和治疗时间的结果.
主要成果:
- 与非西班牙裔白人患者相比,非西班牙裔黑人,亚洲裔和西班牙裔儿科患者呈现出较大的瘤 (p=0.017).
- 西班牙裔患者面部神经牺牲的可能性更高 (OR 3.71,p=0.020).
- 疾病特异性存活率因治疗时间而异 (p=0.01),总体存活率因收入而异 (p<0.001).
结论:
- 根据种族和种族,儿童癌患者的呈现和治疗存在显著差异.
- 这些发现的差异凸显了有针对性的干预措施的必要性,以改善代表性不足的儿科人口获得医疗保健和改善其结果.
- 需要进一步的研究和专注的临床策略来解决儿科瘤学中的这些不平等问题.
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