基于便的测试,用于多肉切除术后结肠直肠癌监测,安全地减少结肠镜检查:MOCCAS研究
Beatriz Carvalho1, Willemijn de Klaver2, Francine van Wifferen3
1Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Gastroenterology
|September 1, 2024
概括
便测试可以安全地减少直肠癌 (CRC) 监测的结肠镜检查高达41%. 便免疫化学测试 (FITs) 为结肠镜检查提供了一种具有成本效益的替代方案,而多目标便DNA测试则更昂贵.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 对于结肠直肠癌 (CRC) 的结肠镜监测是一个巨大的负担.
- 便测试提供了一种潜在的方法,通过识别高风险个体来减少结肠镜检查.
研究的目的:
- 评估用于结直肠癌监测的便测试的准确性和影响.
- 为了确定便测试是否可以安全地减少对结肠镜检查的需要.
主要方法:
- 这是一项对3453名年龄在50-75岁之间的个体进行的横截面观察研究.
- 对比多目标便DNA测试和便免疫化学测试 (FITs) 对结肠镜检查.
- 使用腺瘤和状通路至结肠直肠癌 (ASCCA) 模型进行多角切除术后监测模拟.
主要成果:
- 多目标便DNA测试AUC:0.72;FIT OC-SENSOR AUC:0.61;FIT FOB-Gold AUC:0.59. 便DNA测试AUC:0.72;FIT OC-SENSOR AUC:0.61;FIT FOB-GOLD AUC:0.59. 便DNA测试AUC:0.72;FIT OC-SENSOR AUC:0.61;FIT FOB-GOLD AUC:0.59. 便便DNA测试AUC:0.72;FIT OC-SENSOR AUC:0.61;FIT FOB-GOLD AUC:0.59. 便DNA测试AUC:0.72;FIT OC-SENSOR AUC:0.61;FIT FOB-GOLD AUC:0.59. 便便DNA测试AUC:0.72;FIT OC-SENSOR AUC:0.61;FIT FOB-GOLD AUC:0.59. 便便是最常见的一种便.
- 基于便的策略可以在多眼切除术后减少15%-41%的结肠镜检查.
- 基于FIT的监测节省了成本,而多目标便DNA比结肠镜更昂贵.
结论:
- 以便为基础的多斑切除术后监测是安全有效的.
- 这些策略可以将结肠镜检查的数量减少高达41%.
- 基于FIT的监测是一种成本效益高的结肠镜检查替代方案.
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