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A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

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化功能化基于凝的脚手架用于骨组织工程.

Parinaz Hobbi¹, Forough Rasoulian², Oseweuba Valentine Okoro¹

¹Université Libre de Bruxelles (ULB), École Polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50-CP 165/61, B-1050 Brussels, Belgium.

International journal of biological macromolecules

|September 1, 2024

概括

此摘要是机器生成的。

这项研究开发了一种使用果多二化的凝脚手架,用于骨组织工程. 功能化的支架支持细胞生长,促进骨形成,显示出在再生医学中利用果废物的潜力.

关键词:

骨组织工程骨组织工程化是一种化物.具有多醇功能的脚手架.

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科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
生物技术是生物技术.

背景情况:

聚烯功能化生物材料提供抗氧化,抗炎和骨质诱导的好处,对于骨组织工程 (BTE) 至关重要.
凝 (Gel) 是用于BTE支架的广泛使用的生物材料.
化 (Ph),果副产品中的多,为可持续生物材料开发提供了机会.

研究的目的:

为了使基于凝的脚手架具有化 (Ph) 的功能,用于骨组织工程应用.
评估Ph-功能化的脚手架 (Gel/Ph) 的物理化学,形态学和初步生物特性.
为了研究氧酸盐纳米颗粒 (HA) 结合对凝/基架骨质性潜力的影响.

主要方法:

用化 (Gel/Ph) 功能化的凝脚手架的制造.
脚手架多孔性的特征,毛孔大小,激素清理活动,和的模量.
评估细胞增殖和细胞与介酶干细胞 (MSC) 的细胞相容性.
评估骨质基因表达 (Runx2,ALPL,COL1A1,OSX) 和HA结合的Gel/Ph支架中的矿化.

主要成果:

凝/基架表现出高孔隙度 (71.3 ± 0.3%),合适的孔隙大小 (206.5 ± 1.7 μm) 和显著的激素清理活动 (> 70%).
脚手架表现出良好的机械性能 (Young的模量: 10.8 MPa),支持MSC的增殖,并显示了细胞相容性.
将酸纳米颗粒 (HA) 纳入Gel/Ph支架显著刺激骨质基因表达并促进矿化.

结论:

化功能化的凝支架对BTE具有有利的物理化学和生物特性.
开发的生物材料显示了促进骨质生分化和矿物化的潜力.
利用水果废物衍生的多为开发先进的骨组织工程支架提供了一种可持续的方法.