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通过直接电刺激大脑引发的意识的暂时变化

Julie Lévi-Strauss¹, Julia Makhalova², Samuel Medina Villalon³

¹APHM, Timone Hospital, Epileptology and Cerebral Rhythmology, Marseille, France.

Brain stimulation

|September 1, 2024

概括

发作期间意识的暂时变化与特定的大脑网络变化有关. 这项研究确定了参与意识的关键大脑区域和连接,为新的治疗提供了目标.

科学领域:

神经科学是一个神经科学.
发病学 (Epileptology) 是一个专业的学科.
认知科学认知科学

背景情况:

意识对于环境相互作用至关重要.
意识的暂时变化 (AA) 是发作的特征.
意识的神经基础及其变化仍然在很大程度上是未知的.

研究的目的:

通过电脑刺激诱导的意识 (AA) 暂时变化期间调查大脑功能连接 (FC) 变化.
确定神经枢纽和神经网络对于保持意识至关重要.
为了在诱导AA的刺激过程中比较FC,与没有诱导AA的刺激过程中比较FC.

主要方法:

利用立体电脑电图 (SEEG) 记录患者的大脑活动.
分析了SEEG信号,以评估在体和岛屿刺激期间功能连接 (FC) 的变化.
在诱导AA的刺激过程中比较了FC模式,与负刺激进行了比较.

主要成果:

在AA期间,在脉动性皮层,岛状皮层和状皮层中观察到节点强度下降.
泰拉马斯与岛屿,前额叶,叶和叶皮层之间发现了功能合的减少.
在AA期间,在前皮和时侧皮层之间注意到了增加的同步,在负刺激中缺席.

结论:

肺部,胰岛和顶层皮质是意识网络中的关键枢纽.
了解这些网络动态可以帮助开发的神经调节策略.
这项研究为有针对性的干预提供了基础,以管理引起的意识变化.

关键词:

意识意识意识意识大脑刺激刺激大脑意识的障碍意识的障碍焦点性 - 焦点性神经生理学神经生理学

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