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眼内压力变化对角膜生物力学的影响在初级开角眼中

Yunzhi Xu¹, Yiming Ye¹, Zidong Chen¹

¹From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases (Y.X., Y.Y., Z.C., J.X., Y.Y., Y.Z., P.L., Y.F., K.Y., M.Y.), Guangzhou, China.

American journal of ophthalmology

|September 1, 2024

概括

眼内压力 (IOP) 显著影响角膜生物力学,较低的IOP导致角膜硬度和模量减少. 青光眼的类型影响了这些变化,正常张力的青光眼角膜是最软的.

科学领域:

眼科医生眼科眼科
生物医学工程生物医学工程
玻璃眼研究研究玻璃眼研究

背景情况:

眼内压力 (IOP) 是玻璃眼病发病的一个关键因素.
角膜的生物力学特性在眼睛健康和IOP评估中起着至关重要的作用.
了解IOP和角膜生物力学之间的关系对于青光眼的诊断和管理至关重要.

研究的目的:

为了研究眼内压力 (IOP) 变化和角膜生物机械性质之间的关系.
为了量化内皮压波动和角膜生物力学指标在青光眼患者之间的关系.
在排除了高IOP水平的影响后,在格劳科马亚型之间识别角膜生物力学上的差异.

主要方法:

展望性临床队列研究,涉及初步治疗的患有原发性开角玻璃眼或眼睛高血压 (OHT) 的患者.
通过戈德曼平面化度仪测量IOP;使用角膜和Scheimpflug成像评估角膜生物力学.
在IOP降低药物治疗期间,在一个月内进行重复测量;用于统计分析的配对t测试和ANOVA.

主要成果:

包括81名参与者 (NTG,HTG,OHT);基线角膜硬度和模量明显高于IOP后的减少值 (P < .001).
确定的定量关系:角膜硬度 Δ = 2.06*ΔIOP+6.47 和角膜模量 Δ = 0.017*ΔIOP+0.051 (P < .001).
在IOP降低后,正常张力玻璃眼 (NTG) 角膜的硬度明显低于高压玻璃眼 (HTG) 和OHT角膜 (P < .001).

结论:

IOP变化明显影响角膜生物力学参数,在IOP降低后观察到降低了刚度和模量.
视角生物力学在各类青光眼之间存在差异,即使控制了高IOP效应.
正常血压格劳科马的角膜在生物机械上比高血压格劳科马和眼睛高血压组的角膜柔软.

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