视角:在开发和发布人体临床试验饮食干预措施时的关键考虑因素
Heather J Leidy1, Rachel Gooding2, Kristen Hicks-Roof3
1Department of Nutritional Sciences, University of Texas at Austin, Austin, TX, United States; Department of Pediatrics, Dell Medical School, Austin, TX, United States.
The Journal of nutrition
|September 1, 2024
概括
结合草药和香料可以提高更健康的食物的味道,改善对饮食指南和营养干预措施的遵守. 详细的配方,包括这些增味剂,对于研究可重复性和临床实践至关重要.
科学领域:
- 营养科学 营养科学
- 饮食干预 饮食干预
- 公共卫生 公共卫生
背景情况:
- 美国人饮食指南 (2020-2025) 促进个性化,文化敏感的饮食习惯,以获得高质量的饮食.
- 减少和脂肪,和添加糖的摄入量是具有挑战性的,因为常见的美国消费食品的美味.
- 在营养研究中,坚持更健康的饮食模式往往很低,这归因于诸如减少味道,风味和熟悉度等因素.
研究的目的:
- 探索在人类临床试验中开发文化上适当的配方的最佳实践.
- 为了提高营养干预措施中的饮食坚持和可接受性.
- 突出草药和香料在使更健康的食物选择更有吸引力的作用.
主要方法:
- 这篇视角文章是由2023年营养卫星会议提供信息,重点是临床试验的配方开发.
- 会议讨论了为创建文化敏感和可口的饮食干预措施提出的指导方针.
- 强调了详细的配方信息的重要性,包括特定的食物,准备方法以及草药和香料的使用.
主要成果:
- 草药和香料在维持更健康的食物选择的可接受性方面表现有希望.
- 详细包括食品类型,数量,制备方法和配方是必要的,以实现干预的可重复性.
- 文化上适当的配方开发是改善临床试验中饮食遵守的关键.
结论:
- 整合个人,文化和传统偏好对于建立高质量的饮食至关重要.
- 草药和香料可以显著提高营养干预中更健康的食物的味道和接受度.
- 标准化和详细的配方信息,包括草药和香料,对于研究,指南和实践中的可翻译性至关重要.
相关概念视频
01:16Clinical Trials
6.6K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.6K
01:11Clinical Trials: Overview
2.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.9K
01:28Preclinical Development: Overview
4.3K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.3K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
124
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
124
01:29Nursing Interventions II: Selecting and Classifying the Nursing Interventions
2.1K
Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
2.1K
01:20Study Designs in Epidemiology
193
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
193