营养支持小组干预在患有癌症的儿科患者中的有效性
Midori Shimizu1, Akio Shimizu2, Tetsuya Takamasu3
1Department of Nutrition, Hamamatsu University Hospital.
Journal of nutritional science and vitaminology
|September 1, 2024
概括
儿童癌症患者的营养支持团队干预减少了零人数 (NPO) 订单的事件和天数. 这支持持续的口服摄入,可能改善接受癌症治疗的儿童的治疗结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 临床营养学 临床营养学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 营养不良是儿童癌症患者的一个重大问题,与更差的预后相关.
- 优化营养状况对于改善这种人群的治疗耐受性和结果至关重要.
研究的目的:
- 评估营养支持小组 (NST) 干预措施对预防不良事件和改善儿童癌症患者营养状况的影响.
- 评估NST干预措施是否可以减少对NPO订单的需求,并改善癌症治疗期间的营养标记.
主要方法:
- 一项历史上的队列研究,比较了患有急性淋巴细胞白血病,急性髓性白血病,神经母细胞瘤或脑瘤的儿科患者.
- 干预组接受了NST干预;对照组没有,数据来自不同的入院期 (2013-2014 vs. 2011-2012).
- 用治疗权重的逆概率 (IPTW) 来创建一个同质的概率模型来比较结果.
主要成果:
- 与对照组相比,干预组的NPO订单发生率明显减少 (p=0.037) 并且NPO地位的持续时间更短 (p=0.046).
- 在入院和出院之间的身体质量指数z-score变化中没有观察到显著差异 (p=0.376).
结论:
- 对于儿科癌症患者来说,NST干预与NPO发生率和日数的减少有关.
- 这些发现表明,NST干预促进了持续的口服摄入,这是管理儿科癌症患者的关键因素.
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