幼儿时代的湿疹增加了过敏多发症的风险
L A Miltner1, J M Vonk2,3, J L van der Velde3,4
1Department of Dermatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Clinical and translational allergy
|September 1, 2024
概括
早期出现的持续性湿疹显著增加了儿童患食物过敏,喘和花粉热的风险. 识别有风险的婴儿对于预防过敏多病症至关重要.
科学领域:
- 儿科过敏和免疫学
- 皮肤病学 皮肤病学
- 流行病学 流行病学
背景情况:
- 幼儿湿疹与以后的过敏性疾病有关,如食物过敏 (FA),喘和花粉热.
- 湿疹呈现不同,影响过敏结果.
- 湿疹亚现象可能预测过敏多病症.
研究的目的:
- 在儿童/青少年中,将湿疹表型与FA,喘和花粉热联系起来.
- 描述疾病轨迹,按FA存在分层.
主要方法:
- 使用了TRACKER队列研究 (n=6852).
- 根据发病和持续性研究了七种湿疹表型.
- 使用后勤回归和计算不同年龄段的疾病患病率.
主要成果:
- 在整个童年时期持久性湿疹增加了FA,花粉热和喘的风险.
- "非常早期发病的持续性"湿疹显示出最强烈的关联.
- 在所有年龄段,FA的存在与湿疹,喘和花粉热的明显更高的患病率相关.
结论:
- 这项大型队列研究证实,早期发病的持续性湿疹会增加过敏多发症的风险.
- 早期识别易患早发性湿疹的婴儿对于预防策略至关重要.
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