背部海马-mPFC电路中的活动调节了在不可避免的压力过程中应对压力的策略
Sang Ho Yoon1,2,3, Woo Seok Song1,2, Geehoon Chung1,2,4
1Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Experimental & molecular medicine
|September 1, 2024
概括
背部海马体 (dHP) 中的神经活动通过投射到中间前额叶皮质 (mPFC) 来影响应对压力行为. 这一途径对胺酸至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 分子精神病学分子精神病学
背景情况:
- 背部海马体 (dHP) 参与认知功能,而腹部海马体与情绪过程有关.
- 在与压力相关的行为中,dHP的特定作用及其潜在的神经机制在很大程度上仍未被描述.
研究的目的:
- 研究背部海马神经元活动在调节应对压力行为中的作用.
- 阐明神经回路和分子通路,dHP通过它们影响压力下的行为.
- 探索dHP对胺快速抗抑郁作用的贡献.
主要方法:
- 使用小鼠模型来检查dHP中神经元活动 (c-Fos表达) 在压力和胺管理后.
- 采用分子技术来评估dHP中的突触可塑性标记物 (eEF2,BDNF,ERK) 的变化.
- 应用光遗传和化学遗传工具来操纵dHP神经活动及其投射到中间前额叶皮层 (mPFC).
- 使用尾部悬挂和强迫游泳测试评估行为反应.
主要成果:
- 在dHP中抑制GABAergic传输模仿了胺的分子效应,并在压力测试中降低了不移性.
- 在dHP CA1区域中抑制神经传递的增强诱导了被动应对行为.
- 确定了dHP CA1神经元和mPFC神经元之间的单突触刺激连接.
- 对dHP CA1神经元的光遗传刺激激活了mPFC神经元,对mPFC神经元的化学遗传激活逆转了压力诱导的被动应对.
结论:
- 在dHP中的神经活动调节应对应激的应对策略,以应对不可避免的压力.
- 该dHP通过刺激投射到mPFC发挥其影响,形成一个关键的dHP-mPFC电路.
- 这种dHP-mPFC通路是胺快速抗抑郁作用的关键调解者.
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