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Updated: Aug 3, 2026

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching
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介质细胞和生物物理成分对远端肺器官分化的影响

Olivia Goltsis1,2, Claudia Bilodeau1,3, Jinxia Wang1

  • 1Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.

Stem cell research & therapy
|September 1, 2024
PubMed
概括

介质细胞和机械力量增强了人类多能干细胞衍生的膜器官有机体的发展. 这些发现改善了研究支气管肺功能障碍 (BPD) 等肺部疾病的模型,并测试了新疗法.

关键词:
气膜器官有机物 气膜器官有机物肺部纤维母细胞 肺部纤维母细胞机械应变 机械应变 机械应变多能干细胞是多能干细胞.

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External and Internal Respiration01:24

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External respiration occurs in the lungs, and it is the first step in the journey of oxygen inside the body. When we inhale, oxygen enters our lungs and diffuses across the thin alveolar membrane. The alveoli are tiny, air-filled sacs that provide a vast surface area for gas exchange. Oxygen in the alveoli has a higher partial pressure (105 mmHg) than in the adjacent pulmonary capillaries (40 mmHg), establishing a pressure gradient. As a result, oxygen molecules move from the alveoli into the...