人类血液样本和血液模拟液体的剪切率诱导的粘度变化
Eszter Szabó1, Ernő Zsolt Baka1, Kornél Tamás1
11Department of Machine and Product Design, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Budapest, Hungary.
Acta of bioengineering and biomechanics
|September 2, 2024
概括
这项研究测量了血液粘度和剪切稀释效应,使用旋转类风湿计. 一种特定的血液模仿液体组成,准确地复制了血液.
科学领域:
- 类风病学 类风病学 类风病学
- 生物材料是一种生物材料.
背景情况:
- 准确的粘度测量对于了解血液流动动态至关重要.
- 血液表现出复杂的非牛顿行为,包括剪切稀释和厚度变异.
- 模仿血液的液体对于校准仪器和模拟生理条件至关重要.
研究的目的:
- 测量血液和血液模拟液体粘度在一个广泛的剪切速率 (0.110,000 1/s).
- 为了评估不同测量程序在旋转的风力计上的性能.
- 为了确定一个合适的血液模仿液体组成.
主要方法:
- 分析了来自五位捐献者的血液样本和四个模仿血液的液体组成.
- 粘度测量是使用安东尼帕尔物理MCR301旋转类风湿计进行的.
- 采用了两种不同的测量程序,具有不同的剪速间隔,点数和持续时间.
主要成果:
- 血液表现出显著的剪切稀释和粗的行为,与文献价值一致.
- 模仿血液的液体也表现出剪切稀释和粗的特性.
- 一种由水,甘和粉组成的液体准确地模仿了血液的粘度和行为在37°C.
结论:
- 步骤测试测量程序提供了更稳定的结果,特别是在更高的剪切速度.
- 与文献相比,血液模拟液体结果的差异归因于不同的测量条件.
- 开发出来的水,甘油和粉液在风湿学研究中是一个有前途的血液替代品.
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