在慢性便秘患者的结肠镜检查之前,用林纳克洛提德和1升聚乙烯甘醇加上皮酸进行肠道制备
Natsumi Maeda1, Akira Higashimori1, Ikki Yamamoto2
1Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Scandinavian journal of gastroenterology
|September 2, 2024
概括
将利纳克洛提德添加到聚乙烯甘醇加上酸 (PEG-Asc) 中,显著改善了便秘患者的肠道准备. 与塞纳相比,这种新疗法提高了腺瘤检测率,提供了一个有前途的替代方案.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠癌查 结肠直肠癌查
- 药理学 药理学是指药理学的学科.
背景情况:
- 有效的肠道准备 (BP) 对于结肠镜检查至关重要,但便秘患者的选择有限.
- 之前的组合聚乙烯甘醇加酸 (PEG-Asc) 与 senna 的疗法对这一群体来说不足.
- 作为治疗慢性便秘的药物,林卡洛作为PEG-Asc.的辅助药物进行了研究.
研究的目的:
- 评估林纳克洛提德与PEG-Asc结合在便秘患者的肠道准备中的疗效.
- 在制剂质量和腺瘤检测方面,将这种疗法与PEG-Asc与 senna进行比较.
主要方法:
- 一个回顾性,单中心研究包括543名经过结肠镜检查的便秘门诊患者.
- 患者接受了1L的PEG-Asc与24mg的塞纳或1L的PEG-Asc与500mg的林纳克洛.
- 评估的结果包括不充分的血压率和腺瘤检测率.
主要成果:
- 利纳克洛提德组的血压不足率明显较低 (11%对20%,p<0.01).
- 在利纳克洛提德组中,腺瘤检测率明显高 (54%对45%,p=0.04).
- 多变量分析证实,利纳克洛提德显著降低了不充分血压的风险 (OR=0.36).
结论:
- 与塞纳相比,林纳克洛提德治疗方案显示出更高的血压有效性和更高的腺瘤检测率.
- 耐受性没有受到损害,将利纳克洛提德定位为便秘患者血压的有希望的选择.
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