相关实验视频

Updated: Jun 27, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

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Published on: October 26, 2015

用SAnDReS预测CDK2的抑制:机器学习的应用来导航得分函数空间

Walter Filgueira de Azevedo1

  • 1Department of Physics, Institute of Exact Sciences, Federal University of Alfenas, Av. Jovino Fernandes de Sales 2600, Bairro Santa Clara, Alfenas, MG., 37133-840, Brazil.

Current medicinal chemistry
|September 2, 2024
PubMed
概括

机器学习模型可以有效地预测循环素依赖激酶2 (CDK2) 的抑制. 与其他计算方法相比,SAnDReS程序为CDK2抑制剂构建了优越的预测模型.

关键词:
在CDK2中使用CDK2.机器学习是机器学习.计算模型.计算模型.发现药物的发现.抑制抑制抑制的抑制作用评分功能是一个得分函数.

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Inhibition of Cdk Activity02:34

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...