副转录组:在动脉样硬化进展期间的一个新型调节层
Concetta Schiano1, Ugo Trama2, Enrico Coscioni3
1Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania Luigi Vanvitelli, Italy.
Current medicinal chemistry
|September 2, 2024
概括
RNA表转录组的改变是心血管疾病 (CVD) 和动脉样硬化 (AS) 的关键. 针对这些RNA修改为开发预测生物标志物和精准医学治疗提供了新的途径.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 心脏病学 心脏病学
背景情况:
- RNA修饰,集体称为表体转录体,在细胞过程中发挥关键的调节作用.
- 在心血管疾病 (CVD),包括动脉样硬化 (AS) 中,表皮转录组的变化越来越多地被识别出来.
- 在AS中表体转录组变化的精确的转录和后转录调节机制仍然在很大程度上未被探索.
研究的目的:
- 审查涉及AS的主要表观转录组修饰.
- 讨论当前的RNA修饰剂向策略和潜在的治疗分子.
- 突出表转录体路径作为AS的生物标志物和治疗点的潜力.
主要方法:
- 在AS.中对表表体转录组修改 (m6A,m5C,m1A,m7G, Ψ,A-to-I编辑) 的综合文献综述.
- 对当前针对RNA修饰酶 (如METTL3,FTO,ALKBH5) 的小分子抑制剂和激活剂的分析.
- 探索已识别的植物分子 (例如,Panax notoginseng saponins,rhein) 具有潜在的表体转录组调节作用.
主要成果:
- 关键的表体转录组特征,包括N6-甲基亚丁 (m6A),5-甲基细胞 (m5C) 等,与AS相关.
- 针对像FTO这样的酶的小分子在调节RNA修饰方面表现有前途.
- 莱因等植物分子已经显示出作为FTO抑制剂的潜力,增加mRNA m6A水平.
结论:
- 转录组路径在AS的发病过程中具有重要意义.
- 向RNA表转录组修改为开发预测性,诊断性和预后性生物标志物提供了新的机会.
- 对表皮转录组敏感通路的进一步研究可能会导致对心血管疾病的新精准医学策略.
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