子宫内膜异位症和长期心血管风险:一项全国性的丹麦研究
Eva Havers-Borgersen1, Dorthe Hartwell2, Charlotte Ekelund2,3
1Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
European heart journal
|September 2, 2024
概括
患有子宫内膜异位症的女性面临更高的心血管疾病的长期风险,包括心脏病发作和中风. 这项研究强调了监测子宫内膜异位症患者心血管健康的重要性.
科学领域:
- 生殖医学 生殖医学
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 子宫内膜异位症是一种普遍的妇科疾病,影响到10%的生育年龄女性.
- 它与心血管疾病 (CVD) 有共同的病理生理联系.
- 关于子宫内膜异位症和心血管疾病结局之间的关联的数据有限.
研究的目的:
- 为了调查患有子宫内膜异位症的女性心血管结果的长期风险.
- 解决有关子宫内膜异位症和心血管健康的知识差距.
主要方法:
- 全国范围的丹麦基于登记册的队列研究.
- 包括60508名患有子宫内膜异位症的妇女和242032名匹配的对照 (1: 4比率).
- 从1977年到2021年的随访,评估了心肌梗塞,中风,心律失常,心力衰竭和死亡率等结果.
主要成果:
- 患有子宫内膜异位症的女性患有复合心血管结局的风险明显更高 (调整HR 1.15).
- 观察到心律不整 (调整HR 1.21) 和心力衰竭 (调整HR 1.11) 的风险增加.
- 发现死亡风险降低 (调整HR为0.93).
结论:
- 子宫内膜异位症与心血管结果的长期风险增加有关.
- 这些发现很重要,因为子宫内膜异位症的患病率很高.
- 强调需要对患有子宫内膜异位症的妇女进行心血管风险评估.
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