在怀孕和早产期间长期暴露于环境中的二氧化硫在北卡罗来纳州,2003-2015年
Adrien A Wilkie1,2, Thomas J Luben3, Kristen Rappazzo3
1Oak Ridge Institute for Science and Education (ORISE) Postdoctoral Fellow at US EPA, Research Triangle Park, NC, USA.
概括
来自煤炭厂的二氧化硫 (SO2) 暴露与早产 (PTB) 有关. 在所有种族/种族群体中都观察到关联,有不同影响的证据.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 生殖健康 生殖健康
背景情况:
- 燃煤发电厂对环境二氧化硫 (SO2) 空气污染有很大影响.
- 现有的流行病学研究表明,孕期SO2暴露和早产 (PTB) 之间存在负相关性.
- PTB是婴儿死亡率和长期健康问题的关键因素.
研究的目的:
- 调查北卡罗来纳州SO2暴露与PTB之间的关联.
- 为了确定种族/种族是否改变了SO2和PTB之间的关系.
主要方法:
- 分析了北卡罗来纳州 (2003-2015年) 的单独生育的回顾性队列.
- 美国EPA EQUATES数据被用来估计长期的SO2孕期暴露.
- 采用了多变量通用线性回归模型,对共变量和共同污染物进行调整.
主要成果:
- 中位数的SO2暴露约为1.5 ppb.
- 增加的SO2暴露与所有种族/族群中更高的PTB率有关.
- 在单污染物和多污染物模型中,每增加1ppb SO2的风险差异显著.
结论:
- 证实了SO2暴露和PTB之间的不良关联.
- 有证据表明,在特定的PTB子类别中,因种族/种族而改变潜在效应测量量.
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