脂蛋白的个体内变异性:重复测量的值,用于重新分类中等风险的个体
Tarek Harb1, Efthymios Ziogos1, Roger S Blumenthal1
1Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Johns Hopkins Hospital/Halsted 500, Baltimore, MD 21287, USA.
European heart journal open
|September 2, 2024
概括
脂蛋白[Lp[a]水平可以随着时间的推移而变化,挑战遗传假设. 一次重复的Lp (a) 测量可以完善心血管风险评估,特别是在中等风险人群中.
科学领域:
- 心血管医学 心血管医学
- 遗传学 遗传学 是一个
- 生物化学 生物化学
背景情况:
- 脂蛋白 (Lp) 的水平主要是由基因决定的.
- 重复Lp (a) 测量通常被认为是临床上无助的,因为假定稳定性.
- 对于Lp (a) 的时间变化及其对风险分层的影响尚不清楚.
研究的目的:
- 为了研究Lp (a) 水平的个体内变异性.
- 根据欧洲动脉样硬化学会 (EAS) 的类别来确定重复的Lp(a) 测量是否重新分类心血管风险.
主要方法:
- 来自纳什维尔生物科学数据库的609个人的回顾性队列研究.
- 使用相同的方法分析初始和重复的血清Lp(a) 水平.
- 在EAS风险类别中比较Lp (a) 值和重新分类.
主要成果:
- 在基线和随访Lp(a) 值之间观察到显著差异 (P < 0.05).
- 38.1%的个体显示绝对变化≥10 mg/dL,40.5%的个体显示>25%的变化.
- 在EAS中级"灰色区"类别中,53%的个人转向低风险或高风险. 在黑人个人和女性中发现了更大的变异性.
结论:
- 在Lp的时间变化 (a) 在很大一部分人身上存在.
- 重复Lp (a) 测试可以提高心血管风险预测,特别是最初属于中等风险类别的人.
- 应将Lp (a) 变异性纳入未来针对Lp (a) 向疗法的临床研究.
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