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Francisco Guimarães1, Nataliya Polishchuk1, Cláudia Almeida Martins2

  • 1Internal Medicine, Hospital CUF Descobertas, Lisbon, PRT.

Cureus
|September 2, 2024
PubMed
概括

作为免疫检查点抑制剂的 pembrolizumab 很少能在没有糖尿病病史的患者中诱导糖尿病酸症 (DKA). 对这种罕见的副作用的认识对于接受免疫治疗的癌症患者的及时诊断和管理至关重要.

关键词:
糖尿病 糖尿病患者 糖尿病患者糖尿病酸性酸性糖尿病免疫检查点抑制剂 免疫检查点抑制剂与免疫相关的不良事件免疫疗法 免疫疗法这是一种pd-1抑制剂.

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Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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